Research

An important part of Mitchell’s work is research, trying to find better ways to diagnose and treat eye disease.

He is a clinical academic at the University of Sydney, and an Honorary Research Fellow at Moorfields Eye Hospital in London. Many of his patients kindly give their time to help achieve the goals of improving the diagnosis and management of a range of optic nerve diseases. If you are interested in any of the following studies, please discuss this with Mitchell when you see him.

Research Projects

Imaging in NTG study

Mitchell is the chief investigator on this study that is recruiting patients with normal tension glaucoma (NTG). These are patients with glaucoma who have never had a measured pressure of over 21mmHg. Each patient will have an MRI, some blood tests, and a new OCT scan. The study is investigating whether there is a need to perform an MRI for every patient with NTG, and whether a new OCT scan can differentiate glaucoma from other diseases of the optic nerve.

Fight glaucoma blindness!

Fight glaucoma blindness (FGB) is a registry of patient outcomes in glaucoma. Mitchell is chairing the steering committee that is developing the outcome measures to be used as part of the registry. This database of patient outcomes helps to determine whether new treatments work, and in which patients they are most beneficial.

A randomised controlled trial of a caspase-2 inhibitor (QPI-1007) in the treatment of non-arteritic anterior ischaemic optic neuropathy (NA-AION)

This USA based study has now begun recruitment at Sydney Eye Hospital. Patients with a new onset NA-AION, with symptom onset <14 days, will randomly be assigned to receive the study medication or a placebo. https://clinicaltrials.gov/ct2/show/NCT02341560

Australia and New Zealand Registry of Advanced Glaucoma

This Registry is run by Professor Jamie Craig in Adelaide, and Dr Lawlor contributes by enrolling appropriate patients in the database. If you have advanced glaucoma, chat to Dr Lawlor about whether you may be eligible to be part of this registry. http://anzrag.com

Conference Presentations

  • Should neuroprotective treatment in glaucoma target the entire brain or just the optic nerve? World Glaucoma Congress, June 2017.
  • Addressing glaucoma in low resource countries of the Asia-Pacific Region. 1st Swiss International Ophthalmology Conference. Geneva. June, 2017.
  • Evaluation of a Glaucoma Clinical Referral Pathway Using a Prospective Registry of Glaucoma Outcomes. APAO conference, Singapore, March 2017.
  • Neuroimaging in normal tension glaucoma – when is it necessary? Asia-ARVO, Brisbane, Feb 2017.
  • A technique of abinterno ciliary-sulcus glaucoma tube placement. ANZGIG conference, Brisbane, Jan 2017.
  • Glaucoma progression on OCT – more sensitive to change? RANZCO conference, Melbourne, Nov 2016.
  • Normal tension glaucoma: an update. Sydney Eye Hospital Alumni Conference. July 2016.
  • Vergence eye movements. Neurovision conference. September 2016, Adelaide
  • Rational investigation of neuro-ophthalmic patients in a low resource environment. NANOS meeting, February 2016, Tucson, Arizona
  • A prospective evaluation of colour vision using Ishihara plates in patients with advanced primary open angle glaucoma. NOSA meeting, September 2015, Auckland.
  • Evidence for a lesser relative afferent pupillary defect magnitude in patients with normal tension glaucoma compared to those with glaucoma and elevated intraocular pressures. RANZCO meeting, Wellington, Nov 2015.

Publications

Imaging in NTG study

Mitchell is the chief investigator on this study that is recruiting patients with normal tension glaucoma (NTG). These are patients with glaucoma who have never had a measured pressure of over 21mmHg. Each patient will have an MRI, some blood tests, and a new OCT scan. The study is investigating whether there is a need to perform an MRI for every patient with NTG, and whether a new OCT scan can differentiate glaucoma from other diseases of the optic nerve.

Fight glaucoma blindness!

Fight glaucoma blindness (FGB) is a registry of patient outcomes in glaucoma. Mitchell is chairing the steering committee that is developing the outcome measures to be used as part of the registry. This database of patient outcomes helps to determine whether new treatments work, and in which patients they are most beneficial.

A randomised controlled trial of a caspase-2 inhibitor (QPI-1007) in the treatment of non-arteritic anterior ischaemic optic neuropathy (NA-AION)

This USA based study has now begun recruitment at Sydney Eye Hospital. Patients with a new onset NA-AION, with symptom onset <14 days, will randomly be assigned to receive the study medication or a placebo. https://clinicaltrials.gov/ct2/show/NCT02341560

Australia and New Zealand Registry of Advanced Glaucoma

This Registry is run by Professor Jamie Craig in Adelaide, and Dr Lawlor contributes by enrolling appropriate patients in the database. If you have advanced glaucoma, chat to Dr Lawlor about whether you may be eligible to be part of this registry. http://anzrag.com

  • Evaluation of a Glaucoma Clinical Referral Pathway Using a Prospective Registry of Glaucoma Outcomes. APAO conference, Singapore, March 2017.
  • Neuroimaging in normal tension glaucoma – when is it necessary? Asia-ARVO, Brisbane, Feb 2017.
  • A technique of abinterno ciliary-sulcus glaucoma tube placement. ANZGIG conference, Brisbane, Jan 2017.
  • Glaucoma progression on OCT – more sensitive to change? RANZCO conference, Melbourne, Nov 2016.
  • Normal tension glaucoma: an update. Sydney Eye Hospital Alumni Conference. July 2016.
  • Vergence eye movements. Neurovision conference. September 2016, Adelaide
  • Rational investigation of neuro-ophthalmic patients in a low resource environment. NANOS meeting, February 2016, Tucson, Arizona
  • A prospective evaluation of colour vision using Ishihara plates in patients with advanced primary open angle glaucoma. NOSA meeting, September 2015, Auckland.
  • Evidence for a lesser relative afferent pupillary defect magnitude in patients with normal tension glaucoma compared to those with glaucoma and elevated intraocular pressures. RANZCO meeting, Wellington, Nov 2015.
APPOINTMENTS

You may book an appointment with Mitchell by calling a location convenient to you.